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The Hirshberg Foundation for Pancreatic Cancer Research is proud to announce the following NIH awards, granted to UCLA Investigators who have been Seed Grant recipients from the Foundation.

The National Institutes of Health recognition represents a milestone for the Foundation's mission of funding discoveries of the cause, cure and prevention of pancreatic cancer.

We extend our Congratulations to the following recipients:




NIH Reference #  1 P01 AT003960-01A1
Principal Investigator:  Dr. Vay Liang W. Go
Date of Grant: 09/30/2007 – 09/29/2012
Funding Institution: National Institutes of Health / National Center for Complementary and Alternative Medicine
Total Amount: $5,675,865
Description: UCLA Center for Excellence in Pancreatic Diseases

The goal of this Center for Excellence is to study phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas using molecular biology and metabolomics technology to investigate altered cellular functions.





NIH Reference #  1 R01 CA123273-01A1
Principal Investigator:  Dr. Anthony Heaney
Date of Grant: 10/01/2007 – 09/30/2012
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $1,250,000
Description: Refined Fructose Promotes Pancreatic Cell Growth

The goal of this application is to study the effects of diet rich in fructose on pancreatic cancer cells growth in vitro and in a tumor model.





NIH Reference #  1 R01 CA122042-01A1
Principal Investigator: 

Dr. Guido Eibl

Date of Grant: 08/01/2007 – 05/31/2012
Funding Institution: National Institutes of Health / National Cancer Institute
Total Amount: $1,463,000
Description: The Role of n-3 Polyunsaturated Fatty Acids in Pancreatic Cancer 

This project is designed to explore the efficacy of n-3 polyunsaturated fatty acids in therapy and prevention of pancreatic cancer using xenograft and transgenic animal models of the disease.





NIH Reference #  1 R01 CA104627
Principal Investigator:  Dr. Guido Eibl
Date of Grant: 02/01/2004 – 02/29/2009
Funding Institution: National Institutes of Health / National Cancer Institute
Total Amount: $1,100,000
Description: The Role of COX-2 and PPARY in Pancreatic Cancer




NIH Reference #  R01 DK55003
Principal Investigator:  Dr. Enrique Rozengurt
Date of Grant: 02/28/2008 - 05/30/12
Funding Institution:

National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases

Total Amount: $1,637,250
Description: Gastrointestinal Peptide Signaling through PKC/PKD

The major goals of this project are to characterize the activation of the PKC/PKD pathway and define the role of PKD in proliferative signal transduction in gastrointestinal (GI) cells.




NIH Reference #  R01 DK56930
Principal Investigator:  Dr. Enrique Rozengurt
Date of Grant: 05/30/2006 – 06/01/2011
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $1,356,255
Description: GI Peptide signaling through tyrosine phosphorylation

The major goals of this project are to identify the role of GI peptide-induced tyrosine phosphorylation in signal transduction pathways implicated in cell migration and proliferation.





NIH Reference #  P30 DK41301
Principal Investigator:  Dr. Enrique Rozengurt
Date of Grant: 11/30/2009-11/30/2014
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $4,725,000
Description: CURE: Digestive Diseases Research Center
 

The major goals of the P30 Core Grant are to support multidisciplinary research, transfer of information and the award of seed grants. The CURE: Digestive Diseases Research Core Center Grant supports multiple Scientific Cores, a Pilot and Feasibility Program, the recruitment of a Named New Investigator and an array of Enrichment Activities regarding the function and diseases of the digestive system, including the exocrine pancreas.





NIH Reference #  M01 RR00425-33           
Principal Investigator:  Dr. Paul Lee
Date of Grant: 12/01/2006 – 11/30/2011
Funding Institution: National Institutes of Health/National Center for Research Resources
Total Amount: $732,095
Description: Biomedical Mass Spectrometry Core




NIH Reference #  5 P60 AA11999
Principal Investigator:  Dr. Hidekazu Tsukamoto
Date of Grant: 01/01/2009 – 12/31/2014
Funding Institution: National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism
Total Amount: $756,165
Description: USC-UCLA Southern California Research Center for ALPD and Cirrhosis: Alcohol Abuse and Pancreatic Necrosis

The long-term objective of this project is to determine the role of PKC isotypes in ethanol- induced sensitization of the inflammatory response using in vitro and in vivo models of the pancreas.





VA Merit Award   
Recipient: Dr. Anna Gukovskaya
Date of Grant: 10/01/2006 – 09/30/2010
Funding Institution: Department of Veterans Affairs
Total Amount: $980,000
Description: NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival

This project is designed to determine the effects of pancreatic cancer Nox4 in regulating protein tyrosine phosphatases; and the role of phosphatases in mediating pancreatic cancer cell survival.





VA Merit Award   
Recipient: Dr. Steve Pandol
Date of Grant: 10/01/2007 – 09/30/2011
Funding Institution: Department of Veterans Affairs
Total Amount: $500,000
Description: Inflammation Medicates Necrosis in Pancreatitis
  This project is to determine the effects of infiltrating neutrophils; NADPH oxidase; pharmacologic and genetic inhibition of PI 3kinase; and genetic inhibition of PTEN on pancreatic apoptosis, necrosis, PTEN/Akt system and its downstream pro-apoptic targets during experimental pancreatitis.




AACR Foundation  
Recipient:  Dr. David Dawson
Date of Grant: 07/01/2008 – 06/30/2010
Funding Institution: American Association of Cancer Research
Total Amount: $200,000
Description: Wnt signaling in pancreatic cancer




Past Grants


NIH Reference #  R21 CA137292
Principal Investigator:  Dr. Enrique Rozengurt
Date of Grant: 05/01/2009 – 04/30/2011
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $338,000
Description: Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer

The major goals of this project are to characterize a novel crosstalk between insulin receptor and Gq signaling in human pancreatic cancer cell lines. Furthermore, we will test whether metformin inhibits this crosstalk and offers a novel approach for the treatment of human pancreatic cancer, using tumor xenogafts in nude mice.





NIH Reference #  1 R21 CA124609-01A1
Principal Investigator:  Dr. Oscar Joe Hines
Date of Grant: 07/01/2007 – 06/30/2009
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $308,000
Description: The Role of CXCR2 in Pancreatic Cancer

The study investigates the role of CXCR2 in pancreatic cancer biology and angiogenesis as well as determine chemokine and receptor expression in human specimen.




NIH Reference # 
1 R01 CA119025-01
Principal Investigator: Dr. Anna Gukovskaya
Date of Grant: 07/01/2006 – 05/31/2010
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $300,000
Description: NADPH Oxidase and Pancreatic Cancer Cell Survival

This project is designed to determine the mechanisms of growth factors-induced NADPH oxidase activation in pancreatic cancer cells, as well as the role of this activation in promoting pancreatic cancer cell survival.





NIH Reference #  1 R01 CA104627
Principal Investigator: Dr. Guido Eibl
Date of Grant: 02/01/2004 – 02/29/2009
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $1,100,000
Description:

The Role of COX-2 and PPARY in Pancreatic Cancer





NIH Reference #  R21 AA016840
Principal Investigator: Dr. Ilya Gukovsky
Date of Grant: 07/01/2008 – 06/30/2010
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $275,000
Description: Alcoholic Chronic Pancreatitis Results from Dysregulated Immune Response

This project is designed to determine the mechanism and role of immune regulation by ethanol in mediating chronic alcoholic pancreatitis.





NIH Reference #  1 R21 AA015781-01
Principle Investigator: Dr. Aurelia Lugea
Date of Grant: 07/10/2006 – 06/30/2008
Funding Institution:

National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism

Total Amount:

$275,000

Description:

Plasminogen System and Alcoholic Pancreatitis

 

This project is designed to determine the effects and role of changes in the plasminogen system in alcohol-induced pancreatic disease. There is no scientific or budgetary overlap with any other active or pending project.





VA Merit Award   
Recipient:  Dr. Anna Gukovskaya
Date of Grant: 10/01/2006 – 09/30/2010
Funding Institution: Department of Veterans Affairs
Total Amount: $980,000
Description: NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival

This project is designed to determine the effects of pancreatic cancer Nox4 in regulating protein tyrosine phosphatases; and the role of phosphatases in mediating pancreatic cancer cell survival.





AGA Foundation  
Recipient:  Dr. Olga Mareninova
Date of Grant: 07/01/2007 – 06/30/2010
Funding Institution:

Designated Research Scholar Award in Pancreatitis

Total Amount:

$250,000

Description:

Bcl-2 Proteins Regulate Death Responses of Acute Pancreatitis

 

This project is designed to determine the mechanism and role of immune regulation by ethanol in mediating chronic alcoholic pancreatitis.





 



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