The Hirshberg Foundation for Pancreatic Cancer Research is proud to announce the following NIH awards, granted to UCLA investigators who have been seed grant recipients from the Foundation.
The National Health Institute’s recognition represents a milestone for the Foundation’s mission of funding discoveries of the cause, cure and prevention of pancreatic cancer.
We extend our congratulations to the following recipients:
R21CA37292 (PI: Rozengurt) 05/01/2009-4/30/2011
$169,400/ 1st yr "Targeting crosstalk between insulin and
Gq signaling systems in pancreatic cancer”
P01 AT003960-01A1 (PI: Vay Liang W. Go) 09/30/2007 – 09/29/2012 NIH/NCCAM Total amount: $5,675,865 UCLACenter for Excellence in Pancreatic Diseases
The goal of this Center for Excellence is to study phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas using molecular biology and metabolomics technology to investigate altered cellular functions.
1R01 CA123273-01A1 (PI: Anthony Heaney) 10/1/2007 – 9/30/2012 NIH/NCI Total amount: $1,250,000 Refined Fructose Promotes Pancreatic Cancer Growth
The goal of this application is to study the effects of diet rich in fructose on pancreatic cancer cells growth in vitro and in a tumor model.
1R21 CA124609-01A1 (PI: Oscar Joe Hines) 07/01/2007 – 06/30/2009 NIH/NCI Total amount: $308,000 The Role of CXCR2 in Pancreatic Cancer The study investigates the role of CXCR2 in pancreatic cancer biology and angiogenesis as well as determine chemokine and receptor expression in human specimen.
1R01 CA122042-01A1 (PI: Guido Eibl) 08/01/2007 – 05/31/2012 NIH/NCI Total amount: $1,463,000 The Role of N-3 Polyunsaturated Fatty Acids in Pancreatic Cancer This project is designed to explore the efficacy of n-3 polyunsaturated fatty acids in therapy and prevention of pancreatic cancer using xenograft and transgenic animal models of the disease.
1R01CA119025-01 (Gukovskaya)
09/05/06 – 07/31/10 NIH/NIDDK
$ 60,000x5= $300,000. “NADPH oxidase and pancreatic cancer cell survival” This project is designed to determine the mechanisms of growth factors-induced NADPH oxidase in pancreatic cancer cells, as well as the role of protein tyrosine phosphatases in the effects of NADPH oxidase on the pancreatic cancer cell survival.
VA Merit (Gukovskaya) Merit Award 103 (Gukovskaya)
10/01/06 – 09/30/10 Department of Veterans Affairs
$245,500x5=$1,225,000. “NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival” This project is designed to determine the role and effects of pancreatic cancer NADPH oxidase system in the growth and proliferation of the cancer cells in pancreatic adenocarcinoma. There is no scientific or budgetary overlap with any other active or pending project.
R01 (PI:Eibel)
Current National Institutes of Health, National Cancer Institute: The Role of COX-2 and PPAR-g in Pancreatic Cancer (PI: Eibl)
$1,115,666/yr
R01 DK55003 (Rozengurt) 03/01/03-02/28/08 NIHNIDDK $229,733/yr Role: Principal Investigator “Gastrointestinal Peptide Signaling through PKC/PKD”
The major goals of this project are to characterize the activation of the PKC/PKD pathway and define the role of PKD in GI peptide signal transduction.
R01 DK56930 (Rozengurt) 05/30/06-06/01/11NIH NIDDK $184,000/yr Role: Principal Investigator “GI peptide signaling through tyrosine phosphorylation” The major goals of this project are to identify the intracellular mechanisms leading to rapid GI peptide-induced tyrosine phosphorylation of cellular proteins, including focal adhesion kinase (FAK) and EGF receptor.
5 P30 DK41301 2/01/04-11/30/09
NIH NIDDK $630,000/yr Role: Principal Investigator "CURE: DigestiveDiseasesResearchCenter"
The CURE: DigestiveDiseasesResearchCoreCenter Grant supports an Administrative Core as well as Scientific Cores, including Human Studies, Animal Models, Imaging and Morphology, Molecular Vectors and Proteomics. This Grant also supports a Pilot and Feasibility Program, the recruitment of a Named New Investigator and an array of Enrichment Activities.
