NIH grants awarded to UCLA researchers.

The Hirshberg Foundation for Pancreatic Cancer Research is proud to announce the following NIH awards, granted to UCLA investigators who have been seed grant recipients from the foundation.

The National Health Institute’s recognition represents a milestone for the foundation’s mission of funding discoveries of the cause, cure and prevention of pancreatic cancer.

We extend our congratulations to the following recipients:

 1 P01 AT003960-01A1 (PI: Vay Liang W. Go)
09/30/2007 – 09/29/2012
NIH/NCCAM        
Total amount: $5,675,865
UCLA Center for Excellence in Pancreatic Diseases The goal of this Center for Excellence is to study phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas using molecular biology and metabolomics technology to investigate altered cellular functions.

 1 R01 CA123273-01A1 (PI: Anthony Heaney)
10/1/2007 – 9/30/2012
NIH/NCI    
Total amount: $1,250,000     
Refined Fructose Promotes Pancreatic Cancer Growth The goal of this application is to study the effects of diet rich in fructose on pancreatic cancer cells growth in vitro and in a tumor model.

 1 R21 CA124609-01A1 (PI: Oscar Joe Hines)
07/01/2007 – 06/30/2009
NIH/NCI
Total amount: $308,000
The Role of CXCR2 in Pancreatic Cancer
The study investigates the role of CXCR2 in pancreatic cancer biology and angiogenesis as well as determine chemokine and receptor expression in human specimen.

 1 R01 CA122042-01A1 (PI: Guido Eibl)
08/01/2007 – 05/31/2012
NIH/NCI
Total amount: $1,463,000
The role of n-3 polyunsaturated fatty acids in pancreatic cancer This project is designed to explore the efficacy of n-3 polyunsaturated fatty acids in therapy and prevention of pancreatic cancer using xenograft and transgenic animal models of the disease.

 1R01CA119025-01 (Gukovskaya)                                         09/05/06 – 07/31/10                   NIH/NIDDK                                                                          $ 60,000x5= $300,000.
“NADPH oxidase and pancreatic cancer cell survival”
This project is designed to determine the mechanisms of growth factors-induced NADPH oxidase in pancreatic cancer cells, as well as the role of protein tyrosine phosphatases in the effects of NADPH oxidase on the pancreatic cancer cell survival.

 VA Merit (Gukovskaya)
Merit Award 103 (Gukovskaya)                                             10/01/06 – 09/30/10                   Department of Veterans Affairs                                            $245,500x5=$1,225,000.
“NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival”
This project is designed to determine the role and effects of pancreatic cancer NADPH oxidase system in the growth and proliferation of the cancer cells in pancreatic adenocarcinoma. There is no scientific or budgetary overlap with any other active or pending project.

• R01  (PI:Eibel) National Institutes of Health, National Cancer Institute:            Current
  The Role of COX-2 and PPAR-g in Pancreatic Cancer (PI: Eibl)                       $1,115,666/yr
  
  
• R01 DK55003 (Rozengurt)                                                                   03/01/03-02/28/08
  NIHNIDDK                                                                                                       $229,733/yr 
  Role: Principal Investigator
  “Gastrointestinal Peptide Signaling through PKC/PKD” 
  
  The major goals of this project are to characterize the activation of the PKC/PKD pathway and define the role of PKD in GI peptide signal transduction.