This section includes recent scientific papers from the laboratory of Dr. Rozengurt, the Unit of Signal Transduction and Gastrointestinal Cancer, UCLA Division of Digestive Diseases.
- Lysophosphatidic Acid Rapidly Induces Protein Kinase D Activation through a Pertussis Toxin-Sensitive Pathway.
L. Paolucci, J. Sinnett-Smith and E. Rozengurt.
American Journal of Physiology: Cell Physiology, 278, 33-39, 2000.
- Activation of protein kinase D (PKD) by signaling through the alpha subunit of the heterotrimeric G protein Gq.
J. Yuan, L. Slice, J.H. Walsh and E. Rozengurt.
Journal of Biological Chemistry, 275, 2157-2164, 2000.
- Tyrosine phosphorylation of p125Fak, p130Cas and paxillin does not require ERK activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor.
D. Leopoldt, H.F. Yee, Jr., S. Saab and E. Rozengurt.
Journal of Cellular Physiology, 183, 208-220, 2000.
- Expression and activity of protein kinase D/protein kinase mu in myocardium: Evidence for alpha 1-adrenergic receptor- and protein kinase C-mediated regulation.
R.S. Haworth, M.W. Gross, E. Rozengurt, and M. Avkiran.
Journal of Molecular and Cellular Cardiology, 32, 1013-1023, 2000.
- Protein kinase D: a selective target for antigen receptors and a downstream target for Protein Kinase C in lymphocytes.
S. Matthews, E. Rozengurt, and D. Cantrell.
Journal of Experimental Medicine, 191, 2075-2082, 2000.
- Spatial and Temporal regulation of Protein Kinase D (PKD) in lymphocytes.
S. Matthews, T. Iglesias, E. Rozengurt, and D. Cantrell.
EMBO Journal, 19, 2935-2945, 2000.
- Oxidative stress induces protein kinase D activation in intact cells involvement of Src and dependence on protein kinase C.
R.T. Waldron and E. Rozengurt.
Journal of Biological Chemistry, 275, 17114-17121, 2000.
- Requirement of Cortical Actin Organization for Bombesin/GRP, Endothelin and Epidermal Growth Factor Receptor Internalization in Swiss 3T3 Cells.
J.A. Lunn, H. Wong, E. Rozengurt, and J.H. Walsh.
American Journal of Physiology: Cell Physiology, 279, C2019-C2027, 2000.
- Identification and cloning of Kidins 220, a novel neuronal substrate of protein kinase D.
T. Iglesias, N. Cabrera-Poch, M.P. Mitchell, T.J. Naven, E. Rozengurt, and G. Schiavo.
Journal of Biological Chemistry, 275, 40048-56, 2000.
- [D-Arg(1), D-Trp(5,7,9), Leu(11)] Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3 cells.
J. Sinnett-Smith, C. Santiskulvong, J. Duque, and E. Rozengurt.
Journal of Biological Chemistry, 275(39), 30644-52, 2000.
- CCK2 (CCKB/gastrin) receptor mediates rapid protein kinase D (PKD) activation through a protein kinase C-dependent pathway.
T. Chiu and E. Rozengurt.
FEBS Letters 489, 101-106, 2001.
- Src family kinases are required for integrin-mediated but not for G protein- coupled receptor stimulation of FAK autophosphorylation at Tyr-397.
E.P. Salazar and E. Rozengurt.
Journal of Biological Chemistry, 276, 17788-95 2001.
- Y-27632, a Specific Inhibitor of Rho-associated Kinases, Prevents Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Induced by Bombesin: Dissociation from Tyrosine Phosphorylation of p130cas.
J. Sinnett-Smith, J.A. Lunn, D. Leopoldt and E. Rozengurt.
Experimental Cell Research, 266, 293-302, 2001.
- Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125Fak, p130Cas and paxillin in Swiss 3T3 cells.
D. Leopoldt, H.F. Yee, Jr. and E. Rozengurt.
Journal of Cellular Physiology, 188, 106-119, 2001.
- Protein Kinase D is Sufficient to Suppress EGF Induced c-Jun Ser 63 Phosphorylation.
C. Hurd and E. Rozengurt.
Biochemical and Biophysical Research Communications, 282, 404-408, 2001.
- Gastrin, cck, signaling, and cancer.
E. Rozengurt and J. Walsh.
Annual Review of Physiology, 63, 49-76, 2001.
- G protein-coupled receptor signaling in human ductal pancreatic cancer cells: neurotensin responsiveness and mitogenic stimulation. N.M. Ryder, S. Guha, O.J. Hines, H.A. Reber and E. Rozengurt.
Journal of Cellular Physiology, 186(1), 53-64, 2001.
- Protein Kinase D in Intestinal Epithelial Cells: Rapid Activation by Phorbol Esters, Lysophosphatidic Acid and Angiotensin through Protein Kinase C.
T. Chiu and E. Rozengurt
American Journal of Physiology: Cell Physiology, 280, C929-C942, 2001.
- Agonist-Dependent Immobilization of Chimeric Bombesin/GRP Receptors: Dependence on c-Src Activity and Dissociation from Internalization.
S.H. Young, J.H. Walsh, E. Rozengurt, L.W. Slice.
Experimental Cell Research, 2001 267:37-44, 2001.
- EGF Receptor Function is required in late G1 for Cell Cycle Progression Induced by Bombesin in Swiss 3T3 and Rat-1 cells.
C. Santiskulvong, J. Sinnett-Smith, and E. Rozengurt.
American Journal of Physiology: Cell Physiology, 2001 (In press).
- Rapid protein kinase D translocation in response to G protein-coupled receptor activation: dependence on protein kinase C.
O. Rey, H.S. Young, D. Cantrell, and E. Rozengurt.
Journal of Biological Chemistry, 2001 (In press).
- Activation loop Ser {super744} and Ser {super748} in protein kinase D are transphosphorylated in vivo.
R.T. Waldron, O. Rey, T. Iglesias, T. Tugal, D. Cantrell, and E. Rozengurt.
Journal of Biological Chemistry 276:32606-32615, 2001 (In press).
- Induced Overexpression of Protein Kinase D1 Stimulates Mitogenic Signaling in Human Pancreatic Carcinoma PANC-1 Cells.
- Neurotensin Induces Protein Kinase C-Dependent Protein Kinase D Activation and DNA Synthesis in Human Pancreatic Carcinoma Cell Line PANC-1.
Guha, S., Rey, O., Rozengurt, E.
Cancer Research 62:1632-40, 2002
- Cooperation of Gq, Gi and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acid.
Yuan, J., Slice, L.W., Gu, J., Rozengurt, E.
Journal of Biological Chemistry 278:4882-4891, 2003
- Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists.
Rey, O., Yuan, J., Rozengurt, E.
Biochemical Biophysical Research Communications 302:817-824, 2003
- Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells.
Hurd, C., Rozengurt, E.
Biochemical Biophysical Research Communications 302:800-804, 2003
- Neurotensin Stimulates Protein Kinase C-dependent Mitogenic Signaling in Human Pancreatic Carcinoma Cell Line PANC-1.
Guha, S., Lunn, J. A., Santiskulvong, C., Rozengurt E.
Cancer Research 63:2379-2387, 2003
- Protein kinase C nu/PKD3 nuclear localization, catalytic activation and intracellular redistribution in response to G protein-coupled receptor agonists.
Rey, O., Yuan, J., Young, S.H., Rozengurt, E.
Journal of Biological Chemistry 278:23773-23785, 2003
- Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells.
Young, S. H., Rozengurt, E.
American Journal of Physiology: Cell Physiology 290:C728-C732, 2006
- Protein kinase D signaling.
Rozengurt, E., Waldron, R.T.
Journal of Biological Chemistry 280:13205-13208, 2005
- Broad-Spectrum G Protein-Coupled Receptor Antagonist, [D-Arg1, D-Trp5,7,9,Leu11]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer.
Guha, S., Eibl, G., Kisfalvi, K., Fan, R.S., Burdick, M., Reber, H., Hines, O.J., Strieter, R., Rozengurt, E.
Cancer Research 65:2738-2745, 2005
- Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes.
Lu, Y.C., Sternini, C., Rozengurt, E., Zhukova, E.
Endocrinology 146:2610-2619, 2005
- QDots Nanocrystal Conjugates conjugated to Bombesin or ANG II Label the cognate G Protein-Coupled Receptor in Living Cells.
Lu, Y.C., Sternini, C., Rozengurt, E., Zhukova, E.
Endocrinology 146:2610-2619, 2005
- The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution.
Papazyan, R., Rozengurt E., Rey, O.
Biochemical Biophysical Research Communications 342:685-689, 2006
- The lipid-associated 3D structure of SPA, a broad-spectrum-neuropeptide antagonist with anti-cancer properties.
Keire, D. A., Kumar, M., Hu, W., Sinnett-Smith, J., and Rozengurt, E.
Biophysical Journal 91: 4478- 4489, 2006
- Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq-coupled receptor agonists through an mTOR-dependent pathway.
Kisfalvi, K., Rey, O., Young, S. H., Sinnett-Smith, J., Rozengurt, E.
Endocrinology 148: 3246-57, 2007
- Mitogenic Signaling by G protein-coupled receptors.
Rozengurt, E.
Journal of Cellular Physiology. 213:589-602, 2007
- PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells.
Yuan J., and Rozengurt E.
Journal of Cell Biochemistry. 103: 648-662, 2008
- Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser744 and Ser748 phosphorylation.
Jacamo R, Sinnett-Smith J, Rey O, Waldron RT, Rozengurt E
Journal of Biological Chemistry. 283: 12877-12887, 2008
- Protein kinase D1 mediates NF-{kappa}B activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells.
Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Rozengurt E, Pandol SJ
American Journal of Physiology: Gastrointestinal Liver Physiology. 295: G1190-1201, 2008
- Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.
Sinnett-Smith J, Jacamo R, Kui R, Wang YM, Young SH, Rey O, Waldron RT, Rozengurt E
Journal of Biological Chemistry. 284:13434-13445, 2009
- Metformin disrupts crosstalk between G protein-Coupled Receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.
Kisfalvi K, Eibl G, Sinnett-Smith J, Rozengurt, E
Cancer Research. 69:6539-45, 2009
- Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Kisfalvi K, Hurd C, Guha S, Rozengurt E
Journal of Cellular Physiology. 223:309-16, 2010
- Crosstalk between Insulin/IGF-1 and GPCR Signaling Systems: A Novel Target for the Anti-diabetic Drug Metformin in Pancreatic Cancer.
Rozengurt E, Sinnett-Smith J, Kisfalvi K.
Clinical Cancer Research. 16: 2505-11, 2010
- A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth In vitro and In vivo.
Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherazadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.
Molecular Cancer Therapeutics, 9:1136-46, 2010
- The role of protein kinase D signaling in pancreatic cancer.
Guha S, Tanasanvimon S, Sinnett-Smith J, Rozengurt E.
Biochemical Pharmacology 2010 (in press)
|
|
